Research

• 
  Optical Coherence Tomography & Angiography

  Optical Coherence Tomography (OCT) is a high-resolution, non-invasive imaging technique that utilizes interferometry with low coherence length broadband light. OCT is most widely used in ophthalmology, and developing in other medical specialties such as dermatology, gastroenterology (endoscopy), neurology, oncology, and dentistry.
  
  Optical Coherence Tomography Angiography (OCTA) is an advanced technique form of OCT. OCTA is its ability to use motion contrast in OCT scans to differentiate between blood flow and static tissue. This allows for detailed imaging of vascular anatomy, especially the tiny capillaries in the retina.

• 
  Biosignals measurement system and applications measured through image acquisition technology

  Photoplethysmography (PPG) is a non-invasive technology that uses a light source and a photodetector at the surface of skin to measure the volumetric variations of blood circulation. Bio-signals such as heart rate, respiration, oxygen saturation and pulse wave velocity (PWV) are measured through image acquisition and signal processing through a camera module.
  This non-contact bio-signal measurement technology can be used as a clinical prediction tool for diseases such as cardiovascular, burn, and inflammatory diseases.

• 
  Image guide surgery and therapy

  Photodynamic therapy (PDT) is non-invasive and has fewer side effects than conventional cancer treatment methods because PS (Photosensitizers, PSs) are selectively accumulated in tumors. Optical imaging is possible due to the fluorescence characteristics of PSs, which enables wide area diagnosis (PDD) and fluorescence guided surgery (FGR).
  
  Fluorescence is when a material that absorbs light of a certain wavelength emits light longer than the absorbed wavelength.
  It can determine the location of the sensitizer in real time by overlapping a fluorescence image on a general visible light image.

• 
  Lesion treatment using Photobiomodulation (PBM)

  Photobiomodulation (PBM) changes tissue by irradiating a light source of the wavelength necessary for human tissue at an appropriate intensity based on visible light and near-infrared light in a specific wavelength band.
  A PBM system based on linear polarization technology can be a solution to side effects such as eye damage caused by the high power of existing non-polarized treatment devices.
  
  UVB (ultraviolet B) radiation plays a crucial role in the synthesis of vitamin D in the skin. When skin is exposed to UVB rays from sunlight, a type of cholesterol in the skin is converted into vitamin D. Analyzing the amount of vitamin D synthesis by modulating the frequency of UVB light essential for vitamin D production in experimental mice.
  
  Fluorescence imaging, overlapping with visible light images, enables real-time tracking of moving objects, making it applicable for studying both the behavior and structure of c.elegans.

• 
  Image Processing in Biomedical Applications

  • Whole Slide Image Acquisition
  An automated whole slide image acquisition system has been developed, which is used in pathology and histology to capture high-resolution images of entire microscope slides. Pathologists and researchers can examine the entire slide digitally on a computer screen.
  • Image Stitching
  A sliding template-based image stitching algorithm has been developed for WSI image stitching to seamlessly merge multiple individual microscope images into a larger image. Pathologists and researchers can visualize larger sample areas without compromising resolution.
  • Fluorescence
  A fluorescence imaging system that combines the images acquired using the visible and NIR wavelengths has been developed.
  • SpO2 System
  A SpO2 monitoring system using a dual-source camera involving the use of two light sources to measure blood oxygen saturation levels is being developed. The dual-source camera typically consists of both red and infrared light-emitting diodes (LEDs) or lasers.
  • Virtual Staining
  A deep learning-based algorithm is currently being developed to artificially stain biomedical images.